Fact Check

Are People With Type-A Blood More Susceptible to COVID-19?

Such an observation would have an impact on how medical professionals identify those most at risk of the disease.

Published March 20, 2020

Updated July 8, 2020
Photo Essay From Laboratory. Determination Of Blood Group Abo On Plate. Research Of Erythrocyte Antigens Abo Grouping. There Is An Agglutination Red Blood Cells With The Anti B And Anti Ab Serum But Not With Anti A Serum So The Patient Is Group B. A Drop Of Blood Of The Patient Is Placed With Serums Containing Antibodies Directed Again Antigens A Blue, B Yellow, A Et B Colorless. An Agglutination Of Red Corpuscles Then Indicates The Blood Group Of The Patient. This Research Erythrocyte Antigens Abo Grouping Must Necessarily Be Validated By The Research Of Antibodies In The Serum, And Be Made Twice Independently. (Photo By BSIP/UIG Via Getty Images) (BSIP/UIG Via Getty Images)
Image courtesy of BSIP/UIG Via Getty Images
Claim:
People with Type-A blood are more susceptible to COVID-19.

On March 11, 2020, researchers in China released a preliminary draft of a study that collected data on the ABO blood types of 2,173 patients with lab-verified cases of the COVID-19 coronavirus disease from two hospitals in Wuhan and one in Shenzhen. The researchers compared the distribution of blood types in the infected patients to the distribution of blood types of uninfected people (as a control group) from Wuhan City and Shenzhen City.

The team analyzed the data in an effort to answer two questions. First, if infection from COVID-19 appeared disproportionately high or low in any blood group; and second, if instances of death from COVID-19 had any relationship to blood type. The researchers found that:

  • People with blood Type-A blood were more susceptible to both infection and death from COVID-19.
  • People with blood Type-O were less susceptible to both infection and death from COVID-19.

These results, which the authors cautioned should not be used to guide clinical practice, came with several caveats. First, this study is a draft of a research paper that has not yet been peer-reviewed or published in any journal. Second, the study is limited in both sample size and geographic scope. Speaking to the South China Morning Post, Gao Yingdai, a Tianjin-based researcher not involved in the study, said that while a 2,000-person sample is not necessarily small, it is dwarfed by the number of cases globally.

Tara Moriarty, an expert in infectious diseases and immunopathology with the University of Toronto, told us by email that the study provides "an interesting observation that may have an impact on how we identify those most at risk of disease, but until it has been fully peer-reviewed and confirmed/disconfirmed by additional studies, we cannot yet say if blood type affects susceptibility to COVID-19 infection."

Gao, the Tianjin-based researcher, echoed this point with the Morning Post, saying the results "may be helpful to medical professionals, but ordinary citizens should not take the statistics too seriously" and that "If you are type A, there is no need to panic."

ABO blood type is determined by the the presence or absence of particular sugars and of specific proteins known as antibodies found in the plasma component of blood, as well as the presence or absence of proteins or sugars known as antigens found on the surface of red blood cells. Several viral infections, including Severe Acute Respiratory Syndrome (SARS), appear to have a certain affinity for specific blood types. "Blood type groups are associated with differences in vulnerability to infection with multiple viruses, and severity of outcomes, Moriarity told us. "Examples include HIV, viruses that cause gastrointestinal illness (norovirus, rotavirus), as well as the SARS coronavirus that caused the 2002-2003 SARS outbreak."

The exact mechanism behind difference in how viruses respond to blood types is not well-understood, but may involve how antigens and antibodies inhibit or promote a virus binding to the surface of a cell, Moriarity said.

A newer study published in the New England Journal of Medicine on June 17, 2020, confirmed the results of the Chinese study, but said more research is needed to establish a conclusive link between blood type and COVID-19 susceptibility.

In short, ample scientific evidence exists for the hypothesis that COVID-19 — or other infections — could affect people differently depending on their blood type. However, such a conclusion cannot be made confidently on the basis of the limited research that has been done so far. As such, we rank this claim about blood types as "Unproven."

Sources

Zhao, Jiao, et al.   "Relationship Between the ABO Blood Group and the COVID-19 Susceptibility."     medRxiv preprint.   11 March 2020.

Chen, Stephen.   "People With Blood Type A May Be More Vulnerable to Coronavirus, China Study Finds."     South China Morning Post.   17 March 2020.

National Health Service (UK).   “Blood Groups."     Accessed 20 March 2020.

Cheng, Yufeng, et al.   "ABO Blood Group and Susceptibility to Severe Acute Respiratory Syndrome."     JAMA.   23 March 2005.

Ellinghaus, David, et al.   "Genomewide Association Study of Severe Covid-19 with Respiratory Failure."    NEJM.   17 June 2020.

Updates

Correction [24 March 2020]: Corrected to reflect that antibodies are not sugars.

Updated [8 July 2020]: Added mention of June 2020 study in NEJM.

Alex Kasprak is an investigative journalist and science writer reporting on scientific misinformation, online fraud, and financial crime.