On 21 February 2016, the above-reproduced Facebook photo of Chicago's Trump Tower was shared with the following comment:
Trump challenged Chicagoans by putting his name up on the tower standing mid downtown chicago. For months I drove by and cringed every time I saw his name near the Michigan and Wacker intersection. In response to his selfishness Chicagoans decided to show who they are NOT voting for: — feeling satisfied at Downtown Chicago.
The display apparently caught neither the attention of social media at large (which would have produced a number of shots from other angles) nor the news media, despite its proximity to Trump's win in South Carolina.
The angle and pattern of lit windows in the tower and surrounding buildings are identical in both photos (except for the "NO" in the second photo):
While the "NO" is missing from the first photo, there's an identical pattern of lights on both Trump Tower Chicago and adjacent buildings. That suggests a political protest courtesy of Photoshop, not disgruntled residents of the building.